Most people think immediately of in vitro fertilization (IVF), a type of fertilization that occurs outside the womb, when they contemplate artificial insemination. Intrauterine insemination (IUI) is a less well-known but potentially effective form of artificial insemination. This strategy works well for a range of issues, and is less invasive and costly than IVF. Many couples struggling with fertility issues opt to try IUI before attempting IVF, and many find that the strategy pays off.

Who Should Try

  • Virtually anyone who is a good candidate for IVF is also a good candidate for IUI fertility treatment. People for whom this strategy may be a good option include:
  • Couples and individuals with unexplained infertility.
  • Couples who have trouble getting pregnant due to male erectile dysfunction.
  • Couples for whom a sperm allergy, lack of cervical mucus, or allergy to semen impedes fertility.
  • Couples with a low sperm count or low sperm motility. When the sperm don't have to make the long journey to the egg, fertilization attempts may be more successful.

Intrauterine insemination is a process that allows the sperm to be directly inserted into the uterus to fertilize an egg. This shortens the journey the sperm has to take to the egg. Because IUI fertility treatment requires the monitoring of ovulation, it can also help circumvent issues with intercourse timing and ensure fertilization occurs at the optimal time for a pregnancy to occur.

IUI will not work for people who have structural abnormalities that render implantation impossible, nor for women who do not ovulate at all. In some women with autoimmune or inflammatory diseases, IUI may fail because the body rejects the developing embryo.

IUI can be done with almost no preparation, and does not require the woman to take hormones prior to the procedure. However, a woman with other reproductive issues—such as hormonal imbalances—may benefit from hormone therapy prior to an IUI insemination. And because more eggs mean a greater chance of successful fertilization, it is sometimes prefered to have the woman take stimulating drugs that increase egg production prior to an IUI procedure. You will also be made aware of the relative risks and benefits of this strategy.

Is Intrauterine
Insemination Safe?

IUI does not require the use of hormones or medications, which means the risks of side effects is minimal. Because it is a non-invasive procedure, the woman is unlikely to experience serious health problems. Discomfort is minimal, and the procedure itself takes only a few minutes. The man must only donate sperm, which is a completely safe and unobtrusive procedure.

As with all fertility treatments, IUI does come with some risks if there is already a health problem. For example, a woman with a history of recurrent miscarriages could suffer another miscarriage after an IUI procedure, and this in turn could trigger a number of physical and psychological health problems. In general though, intrauterine insemination is one of the safest fertility treatment options.


No two people are the same, and no two infertility cases are alike. Your fertility status is personal and unique to you. Schedule your assessment with one of our fertility specialists.
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